Table 1

The top significant SNPs of their associated gene from single-marker analysis (P < 2.8 × 10−6)

SNPChr:positionGeneAllelesEAFβSEPN
rs626511:27679916BDNFT/C0.1951−0.04120.00211.0 × 10−86795,458
rs749866516:28883241SH2B1A/G0.5962−0.02710.00175.6 × 10−60790,299
rs381488316:29994922KCTD13T/C0.47640.02320.00171.1 × 10−40685,519
rs87962016:4015729CREBBPT/C0.61790.02310.00185.3 × 10−38688,377
rs716472715:73093991BBS4T/C0.6810.01820.00173.3 × 10−25791,156
rs9468241:243684019SDCCAG8T/C0.1410.02060.00261.1 × 10−15689,849
rs1244873816:56489343BBS2A/C0.8629−0.01680.00252.8 × 10−11691,932
rs122065646:100987009SIM1T/C0.505−0.01130.00175.4 × 10−11689,836
rs11873529:87293457NTRK2T/C0.3482−0.01190.00186.0 × 10−11688,522
rs12603262:27730940IFT172T/C0.4027−0.01050.00173.9 × 10−10784,462
rs117920699:140646121EHMT1A/G0.830.01450.00246.5 × 10−10644,252
rs797579112:49413486KMT2DT/C0.03601−0.02640.00431.1 × 10−9770,139
rs1262889122:38317137SOX10T/C0.3169−0.01120.00193.0 × 10−9686,575
rs124785562:63341711WDPCPA/T0.41770.01030.00184.5 × 10−9683,709
rs1164986417:56093061MKS1A/G0.091270.01780.00316.7 × 10−9663,638
rs13953122:41676176EP300A/G0.71970.01120.00199.5 × 10−9690,810
rs8813018:38332318FGFR1T/C0.5818−0.00970.00172.4 × 10−8691,753
rs69019446:56862805RAB23A/G0.8344−0.01260.00232.7 × 10−8692,035
rs69101176:84971679MRAP2A/T0.9099−0.01570.00299.1 × 10−8643,225
rs1280513311:66483265BBS1A/G0.5426−0.00910.00183.5 × 10−7635,477
rs602656720:57444915GNASA/G0.571−0.00920.00184.4 × 10−7659,708
rs961056022:37064378IFT27A/G0.7375−0.00990.0025.1 × 10−7671,468
rs177650883:45943595LZTFL1C/G0.8817−0.01360.00275.7 × 10−7666,309
rs131714145:37232079NIPBLA/G0.78360.01030.00217.2 × 10−7692,376
rs1116134715:23948049MAGEL2/MKRN3/NDNA/G0.48310.00850.00181.1 × 10−6672,682
rs133116087:32999601BBS9A/G0.5147−0.00830.00171.3 × 10−6688,219
rs75257917:17660347RAI1T/C0.60770.00820.00171.6 × 10−6781,905
  • Novel SNPs are shown in bold. Chromosome (Chr):position, Alleles (effect/other), effect allele frequency (EAF), beta (β), SE, P values, and number of observations (N) are reported. SNP positions are reported according to Build 37. See Supplementary Table 2 for the complete results from single-marker analysis.