Table 4

Meta-analysis of the UKB and GIANT Consortium and the EGG Consortium with a random-effects model of the top SNPs of genes identified by single-marker, tagSNP, and gene-based analyses in the EGG Consortium

SNPChr:positionGeneAllelesβPI2
rs626511:27636492BDNFT/C−0.04151.14E−900
rs749866516:28790742SH2B1A/G−0.02724.39E−600
rs381488316:29902423KCTD13T/C0.02311.78E−430
rs87962016:3955730CREBBPT/C0.02338.09E−400
rs716472715:70881044BBS4T/C0.01835.98E−280
rs122065646:101093730SIM1T/C−0.01154.86E−120
rs1244873816:55046844BBS2A/C−0.01661.28E−110
rs13953122:40006122EP300A/G0.01156.52E−100
rs1262889122:36647083SOX10T/C−0.01131.38E−090
rs124785562:63195215WDPCPA/T0.01026.14E−090
rs69019446:56970764RAB23A/G−0.0137.87E−090
rs69101176:85028398MRAP2aA/T−0.01538.77E−080
rs11873529:86483277NTRK2T/C−0.01132.72E−074.69
rs133116087:32966126BBS9aA/G−0.00835.85E−070
rs38914004:123955799BBS12bT/G−0.01197.29E−060
rs119508135:42778662GHRcA/G0.00838.44E−060
rs748416811:8273405TUBbA/C−0.00761.68E−050
rs9468241:241750642SDCCAG8T/C0.01745.87E−0334.7
rs117920699:139765942EHMT1A/G0.01251.15E−0221.87
rs8813018:38451475FGFR1T/C−0.01311.72E−0251.45
rs131714145:37267836NIPBLaA/G0.01453.06E−0252.97
rs961056022:35394324IFT27aA/G−0.00833.71E−0221.08
rs75257917:17601072RAI1T/C0.01699.22E−0284.53
rs797579112:47699753KMT2DT/C−0.01464.00E−0160.08
rs126750388:117775399RAD21bT/C0.0064.63E−0155.33
rs611675020:5251842PROKR2cT/C0.00375.39E−0156.01
rs188183715:91266191CHD2cA/G−0.00416.26E−0162.2
rs1280513311:66239841BBS1aA/G0.0057.40E−0192.07
rs177650883:45918599LZTFL1aC/G−0.0047.60E−0169.18
rs1116134715:21499142MAGEL2/MKRN3/NDNaA/G−0.0038.15E−0188.91
rs12603262:27584444IFT172T/C0.00348.19E−0192.65
rs602656720:56878310GNASaA/G−0.00178.57E−0177.9
rs1164986417:53448060MKS1A/G0.00288.78E−0181.01
  • Significant SNPs (P < 1.52 × 10−3) are shown in bold. Chr, chromosome. Heterogeneity between studies was assessed using the I2 statistic.

  • aNovel genes identified by single-marker analysis.

  • bNovel genes identified by tagSNP analysis.

  • cNovel genes identified by gene-based analysis.