Table 2

Association of SNPs with circulating PEDF level

Nearest gene(s)SNPA1A2Discovery (N = 2,936)Replication (N = 2,449)Combined (N = 5,385)
MAFβ (SE)P value*MAFβ (SE)P valueDirβ (SE)P value
SERPINF1rs1136287CT0.452−0.32 (0.03)3.93 × 10−350.463−0.33 (0.03)9.32 × 10−32− −−0.33 (0.02)2.06 × 10−57
SMYD4rs7224496AC0.3210.25 (0.03)1.07 × 10−180.3230.19 (0.03)5.07 × 10−10+ +0.22 (0.02)7.56 × 10−25
SERPINF2rs2070863TC0.184−0.18 (0.03)3.73 × 10−80.176−0.09 (0.04)0.021− −−0.15 (0.02)8.22 × 10−10
TENM2rs9313307AC0.1180.17 (0.04)1.90 × 10−50.119−0.03 (0.05)0.540+ −0.08 (0.03)5.63 × 10−3
ITGAVrs61757099GA0.005−0.75 (0.18)2.44 × 10−50.0050.06 (0.20)0.758− +−0.38 (0.13)4.18 × 10−3
NQO2rs28383651CT0.0160.42 (0.10)4.00 × 10−50.019−0.06 (0.10)0.589+ −0.19 (0.07)8.31 × 10−3
TNP1/DIRC3rs17778798CT0.0590.22 (0.05)4.04 × 10−50.0620.08 (0.06)0.176+ +0.16 (0.04)2.32 × 10−5
  • The βs are reported with respect to the minor allele. A1, minor allele; A2, major allele; Dir, direction of effect.

  • *Adjusted for age, sex, and two PCs.

  • †Adjusted for age and sex.