Table 2

TGD, nonoxidative glucose disposal, glucose oxidation, and rEGP (primarily reflects hepatic) during the insulin clamp before and after glucose infusion

FHFH+Control
Baseline insulin clamp
 Steady-state plasma glucose (mg/dL)94.8 ± 1.895.9 ± 1.694.9 ± 3.3
 Steady-state plasma insulin (µU/mL)163 ± 2172 ± 12125 ± 8
 bEGP (mg/kg/min)2.33 ± 0.082.09 ± 0.092.46 ± 0.11
 bEGP × basal insulin ([µU/mL] · [mg/kg/min])20.5 ± 1.919.3 ± 4.219.2 ± 1.7
 TGD (mg/kg/min)11.49 ± 0.919.32 ± 0.49*11.18 ± 1.64
 rEGP (mg/kg/min)0.56 ± 0.20.56 ± 0.330.34 ± 0.26
 Basal glucose oxidation (mg/kg/min)1.33 ± 0.131.14 ± 0.181.34 ± 0.13
 Clamp glucose oxidation (mg/kg/min)2.75 ± 0.531.81 ± 0.26*2.45 ± 0.17
 Nonoxidative glucose disposal (mg/kg/min)8.69 ± 0.827.46 ± 0.618.35 ± 1.88
 Basal LOX (mg/kg/min)0.92 ± 0.100.94 ± 0.090.99 ± 0.19
 Clamp LOX (mg/kg/min)0.50 ± 0.080.74 ± 0.110.45 ± 0.2
 Basal RER0.81 ± 0.020.80 ± 0.020.81 ± 0.02
 Clamp RER0.90 ± 0.020.85 ± 0.020.91 ± 0.03
Insulin clamp post–glucose infusion
 Steady-state plasma glucose (mg/dL)96.1 ± 2.098.1 ± 1.496.9 ± 2.0
 Steady-state plasma insulin (µU/mL)208 ± 24198 ± 10121 ± 8
 bEGP (mg/kg/min)3.87 ± 0.37††3.63 ± 0.27††2.27 ± 0.11
 bEGP × basal insulin ([µU/mL] ⋅ [mg/kg/min])74.9 ± 12.8††59.1 ± 5.5†††20.4 ± 1.0
 TGD (mg/kg/min)9.46 ± 0.69†††8.12 ± 0.55††10.65 ± 1.61
 rEGP (mg/kg/min)0.54 ± 0.220.47 ± 0.110.14 ± 0.09
 Basal glucose oxidation (mg/kg/min)4.64 ± 0.393.78 ± 0.251.35 ± 0.18
 Clamp glucose oxidation (mg/kg/min)5.12 ± 0.374.39 ± 0.293.03 ± 0.21
 Nonoxidative glucose disposal (mg/kg/min)4.28 ± 0.604.11 ± 0.697.61 ± 1.69
 Basal LOX (mg/kg/min)−0.14 ± 0.120.14 ± 0.060.86 ± 0.04
 Clamp LOX (mg/kg/min)−0.15 ± 0.120.09 ± 0.080.42 ± 0.11
 Basal RER1.0 ± 0.020.97 ± 0.010.81 ± 0.01
 Clamp RER1.0 ± 0.020.98 ± 0.010.92 ± 0.01
  • Data are mean ± SE. LOX, lipid oxidation.

  • *P < 0.05, FH+ vs. FH.

  • P < 0.001, post–glucose infusion vs. baseline.

  • ††P = 0.08, post–glucose infusion vs. baseline.

  • †††P = 0.02, post–glucose infusion vs. baseline.