Table 3

Significance of associations between fasting glucose known genetic determinants and fructosamine and percent glycated albumin in ARIC

SNPChr:positionClosest geneA1/A2WhitesBlacks
A1 freqP value fructosamineP value glycated albuminP value fasting glucoseA1 freqP value fructosamineP value glycated albuminP value fasting glucose
rs1074708312:133041618P2RX2G/A0.330.950.760.140.160.170.110.95
rs1083096311:92708710MTNR1BG/C0.280.0010.0033.3E-070.070.130.030.38
rs1088512210:113042093ADRA2AT/G0.120.820.750.760.680.240.720.21
rs1107165715:62433962C2CD4BG/A0.380.500.810.520.120.980.950.43
rs115584718:118185733SLC30A8G/A0.320.0058.2E-051.8E-050.090.310.180.65
rs1160333411:72432985ARAP1A/G0.160.010.080.470.060.790.950.76
rs1160592411:45873091CRY2A/C0.470.360.580.660.840.580.720.44
rs117080673:123065778ADCY5G/A0.230.070.0010.010.160.0020.0030.03
rs117159153:49455330AMTT/C0.300.300.740.040.230.060.370.31
rs119200903:170717521SLC2A2A/T0.130.0040.0020.340.350.470.300.28
rs131790485:95542726PCSK1A/C0.310.110.130.510.080.180.520.78
rs13716142:27152874DPYSL5T/C0.250.470.780.690.360.180.110.21
rs1433997679:96182703YRNAC/A0.010.650.240.55
rs148312111:48333360OR4S1A/G0.130.410.360.740.040.460.420.94
rs169136939:111680359IKBKAPG/T0.030.600.780.110.250.730.680.91
rs17455011:61571478FADS1C/T0.330.160.280.540.080.370.150.93
rs177624546:7213200RREB1T/C0.260.130.320.0010.160.160.760.75
rs21913497:15064309TMEM195, DGKBG/T0.460.170.360.020.440.580.730.004
rs229394113:28491198PDX1A/G0.220.020.0050.030.170.380.600.77
rs230259319:46196634GIPRG/C0.501.000.400.020.300.640.940.97
rs265787912:56865338GLS2G/A0.180.930.940.310.060.050.230.04
rs27224258:40484239ZMAT4T/C0.120.010.010.780.370.250.350.41
rs3408741:214159256PROX1T/C0.450.420.820.400.170.360.740.15
rs3576712:102875569IGF1G/A0.160.760.540.620.550.430.100.02
rs37365942:27995781MRPL33C/A0.260.110.070.250.430.070.030.62
rs378334714:100839261WARST/G0.220.450.510.570.060.440.600.94
rs38291099:139256766DNLZA/G0.290.0030.130.160.180.510.390.46
rs450656510:114756041TCF7L2T/A0.313.9E-042.5E-052.7E-050.440.090.400.83
rs46075177:44235668GCKA/G0.172.0E-040.0035.0E-040.110.090.100.08
rs48411328:9183596PPP1R3BA/G0.090.330.320.050.130.740.290.05
rs5608872:169763148G6PC2T/C0.300.080.0037.3E-050.050.810.580.91
rs57667413:33554302KLG/A0.160.450.500.330.610.170.260.11
rs604820520:22559601FOXA2G/A0.050.790.950.070.180.020.250.05
rs607227520:39743905TOP1A/G0.160.570.300.010.080.130.120.08
rs69431537:50791579GRB10T/C0.310.670.460.160.700.090.770.61
rs70342009:4289050GLIS3A/C0.490.190.040.030.610.180.020.11
rs76510903:185513392IGF2BP2G/A0.310.010.030.0030.560.320.580.40
rs77082855:76425867ZBED3G/A0.300.320.640.710.150.560.520.16
rs7800942:27741237GCKRT/C0.400.055.7E-051.0E-040.180.750.960.90
rs794458411:47336320MADDT/A0.270.560.760.050.040.980.380.77
rs93682226:20686996CDKAL1A/C0.270.190.090.270.200.960.800.68
  • freq, frequency. Candidate SNPs selected from NHGRI database based on previous genome-wide significant associations. P values that reach study-wide significance for fructosamine and glycated albumin, P < 3.0 × 10−4 (0.05/(2*2*41)), and P values that reach nominal significance (P < 0.05) for fasting glucose are in boldface type.