Table 3

Test for interaction between vitamin D gene SNPs and the 25(OH)D variables on risk of IA

GeneSNP (minor allele)Minor allele frequencyNominal P value (P value adjusted by false discovery rate)* for SNP interaction with
Childhood 25(OH)D concentrationEarly infancy 25(OH)D concentrationChildhood vitamin D sufficiencyEarly infancy vitamin D sufficiency
GCrs7041 (T)0.420.67 (0.96)0.20 (0.60)0.19 (0.34)0.15 (0.45)
CYP27B1rs4646536 (C)0.330.29 (0.70)0.93 (0.96)0.46 (0.59)0.52 (0.71)
CYP24A1rs4809959 (A)0.500.51 (0.92)0.96 (0.96)0.04 (0.12)0.63 (0.71)
CYP24A1rs2616277 (A)0.170.85 (0.96)0.62 (0.80)0.61 (0.61)0.83 (0.83)
VDR (BsmI)rs1544410 (A)0.390.23 (0.70)0.03 (0.14)0.18 (0.34)0.15 (0.45)
VDR (ApaI)rs7975232 (C)0.460.0072 (0.06)0.0019 (0.017)0.01 (0.09)0.0051 (0.046)
VDR (Cdx2)rs11568820 (A)0.190.31 (0.70)0.51 (0.77)0.04 (0.12)0.61 (0.71)
RXRArs3818740 (C)0.290.91 (0.96)0.47 (0.77)0.41 (0.59)0.31 (0.56)
RXRArs10881582 (A)0.250.96 (0.96)0.28 (0.63)0.56 (0.61)0.21 (0.47)
  • All models include HLA-DR3/4 status and the first two PCs indicating ancestry. For the early infancy vitamin D exposures, we also adjusted for age and season of sample collection at the first visit.

  • *The nominal P value of the interaction term is from the Wald test. In parentheses, we provide the P value corrected by the false discovery rate (28).

  • †Average of measures from all visits prior to and including the seroconversion visit.

  • ‡The first 25(OH)D measure occurring before 12 months of age in 360 case subjects and their 981 control subjects.