TABLE 3

Regression data for the PVA-MVO2 relationships from individual experiments with hearts from control (db/+), type 2 (db/db), and type 1 (STZ-administered db/+) diabetic mice at low and high fatty acid perfusate

Low fatty acids
High fatty acids
y-intercept · 10−2Sloper2y-intercept · 10−2Sloper2
db/+
    12.51.80.832.52.00.98
    22.02.40.952.42.60.93
    31.83.20.972.13.10.98
    41.42.80.911.92.80.95
    52.92.10.863.12.50.93
    Means ± SE2.1 ± 0.32.5 ± 0.30.91 ± 0.032.4 ± 0.2*2.6 ± 0.20.95 ± 0.01
db/db
    13.72.10.963.82.40.88
    24.82.50.944.52.80.96
    33.01.40.952.61.60.89
    44.03.20.892.93.60.88
    54.02.90.874.13.30.93
    64.71.90.903.82.90.98
    73.42.30.973.52.30.90
    Mean ± SE3.9 ± 0.32.3 ± 0.30.92 ± 0.023.6 ± 0.32.7 ± 0.3*0.92 ± 0.02
STZ
    13.02.00.983.32.10.98
    23.22.00.973.52.61.00
    32.52.70.952.22.90.98
    42.91.80.873.11.70.98
    53.81.70.953.61.80.93
    64.02.00.924.21.80.94
    73.81.60.953.51.80.97
    Mean ± SE3.3 ± 0.22.0 ± 0.10.94 ± 0.013.3 ± 0.32.1 ± 0.20.97 ± 0.01
  • The y-intercept represents MVO2 for unloaded hearts, expressed as Joules · beat−1 · gram dry heart wt−1. Slope is dimensionless, whereas r2 is the square of the regression coefficient. Only experiments with a regression coefficient >0.9 (r2 ≥0.81) were included.

  • *

    * P < 0.05 vs. low fatty acids;

  • P < 0.05 vs. db/+ hearts.