TABLE 3

Common and rare (frequency >1%) haplotypes across 15 SNPs in 1,506 subjects sorted by change in adiponectin concentrations for those carrying one copy of the haplotype compared with those with two copies of the most common haplotype (H22) from the general linear regression model with log(adiponectin + 1) as the outcome adjusted for age and sex and with corresponding P value testing for the difference of this change from zero

Haplotypes
Frequency*Δadiponectin for 1 (2) haplotype(s) (μg/ml)P
Block 1 SNP number: 2345679Block 2 SNP number: 11111111 12345678
H12T-C-G-A-T-T-C-T-A-T-G-G-T-G-G0.023 ± 0.003−2.00.0000008
H20T-C-G-G-G-T-C-T-A-T-G-G-T-G-G0.019 ± 0.002−0.90.04
H17T-C-G-G-G-C-C-T-A-T-G-G-T-A-G0.011 ± 0.002−0.6>0.05
H19T-C-G-G-G-T-C-T-A-T-G-G-T-A-G0.031 ± 0.003−0.4>0.1
H11T-C-G-A-T-T-C-T-A-T-G-G-T-A-G0.066 ± 0.003−0.3>0.1
H23T-C-G-G-G-T-C-T-G-T-T-A-T-G-G0.039 ± 0.004−0.1>0.1
H22T-C-G-G-G-T-C-T-G-T-G-G-T-A-G0.124 ± 0.006Reference
H24T-C-G-G-T-C-A-T-G-T-G-G-T-A-G0.044 ± 0.0040>0.1
H26T-T-G-A-T-C-A-T-G-T-G-G-T-A-G0.096 ± 0.0050.3 (0.9)>0.1
H6T-C-G-A-G-T-C-T-A-T-T-A-T-G-G0.010 ± 0.0020.5>0.1
H8T-C-G-A-T-T-C-G-G-T-T-A-T-G-G0.054 ± 0.0040.60.06
H16T-C-G-A-T-T-C-T-G-T-T-A-T-G-G0.100 ± 0.0050.8 (2.6)0.0005
H9T-C-G-A-T-T-C-T-A-G-G-A-T-G-C0.066 ± 0.0050.80.007
H21T-C-G-G-G-T-C-T-G-T-G-G-C-A-G0.025 ± 0.0030.90.03
H15T-C-G-A-T-T-C-T-G-T-G-G-T-A-G0.093 ± 0.0050.9 (1.5)0.0003
H4T-C-A-A-T-T-C-T-G-T-T-A-T-G-G0.019 ± 0.0021.60.002
H2C-C-A-A-T-T-C-T-G-T-T-A-T-G-G0.053 ± 0.0041.80.00000002
H1C-C-A-A-T-T-C-T-A-G-G-A-T-G-C0.016 ± 0.0022.50.00002
  • *

    * Expected haplotype frequency and SE;

  • assuming a trend per copy, adjusted for age and sex.