TABLE 1

Effect of diabetes and treatment with enalapril and l-158809 on body weight, blood glucose, and superoxide levels in the aorta

ConditionsnFinal weight (g)Blood glucose (mg/dl)Aorta superoxide (RLU)
Control (group 1)8469 ± 1981 ± 32.39 ± 0.20
Diabetic (group 1)8291 ± 25*495 ± 21*5.87 ± 0.45*
Diabetic + enalapril (group 1)9292 ± 18*461 ± 11*2.86 ± 0.22
Diabetic + l-158809 (group 1)9294 ± 11*447 ± 20*3.42 ± 0.46
Control (group 2)9482 ± 767 ± 62.67 ± 0.21
Diabetic (group 2)9297 ± 15*475 ± 14*5.10 ± 0.38*
Diabetic + enalapril (group 2)9305 ± 17*479 ± 31*3.35 ± 0.27
Diabetic + l-158809 (group 2)10304 ± 24*481 ± 19*3.28 ± 0.27
Control (group 3)8524 ± 1273 ± 22.88 ± 0.29
Diabetic (group 3)9293 ± 22*417 ± 20*5.14 ± 0.37*
Diabetic + enalapril (group 3)8298 ± 30*494 ± 18*3.14 ± 0.35
Diabetic + l-158809 (group 3)9285 ± 15*481 ± 18*3.23 ± 0.40
Control (group 4)9514 ± 1173 ± 32.88 ± 0.22
Diabetic (group 4)8312 ± 14*407 ± 22*5.25 ± 0.31*
Diabetic + enalapril (group 4)9313 ± 23*465 ± 23*3.62 ± 0.38
Diabetic + l-158809 (group 4)10306 ± 14*471 ± 15*4.34 ± 0.47*
  • Data are means ± SE.

  • *

    * P < 0.05 compared with control rats;

  • P < 0.05 compared with diabetic rats.