QTL replication and locus-by-diet interactions

Adiposity QTLChromo-someMarkers testedReplication probabilityTraits significantly affected by locus-by-diet interactions
Adip 11D1Mit780.13910-week AUC(f), 20-week AUC(m), mesenteric/total fat(m)
Adip 26D6Mit140.726Renal fat(m), mesenteric fat, inguinal fat(m), triglycerides(m), total fat(m), renal/body(m), inguinal/body(m), reproductive/total(m), inguinal/total(m), adiposity(m)
D6Mit580.023Postweaning growth, adult growth(m)
Adip 37D7Mit1480.00420-week AUC, adult growth, inguinal/body(m), mesenteric/body(m), adiposity(m)
Adip 48D8Mit560.613Free fatty acids(f), spleen(f), mesenteric/total(m)
Adip 59D9Mit80.004Renal fat, reproductive/body(m), reproductive/total(m)
D9Mit190.09510-week basal glucose(f), insulin(f), liver(f)
Adip 612D12Mit50.014None
Adip 713D13Mit10.156Insulin(m), liver(m), 20-week basal glucose(m), reproductive fat(m), total fat(m), reproductive/body(m)
D13Mit1150.027Insulin, kidney, reproductive fat, inguinal fat(f), total fat, heart(f), liver(f), triglycerides(m), insulin(m), reproductive/body, inguinal/body, reproductive/total(m), reproductive/total(f), adiposity
Adip 818D18Mit510.027Free fatty acids(m)
  • Adiposity QTLs are taken from Cheverud et al. (22). Chromosomal location and markers chosen to test for replication and interactions are indicated. All QTLs with the exception of Adip1 and Adip4 replicated for at least one of the associated markers tested. All loci replicated in the sample were fed a low-fat diet with the exception of Adip7, which only replicated in female animals fed a high-fat diet. Traits that are significantly affected by diet-by-genotype interactions for each locus are shown in the right-hand column. Sex-specific effects are indicated by (f) for female-specific effects or (m) for male-specific effects.