TABLE 2

Glucagon secretion from mouse islets

0.5 mmol/l glucose (% of content/h)10 mmol/l glucose (% of content/h)
No additions0.095 ± 0.0110.055 ± 0.008 *
17 nmol/l insulin0.053 ± 0.008 *0.054 ± 0.009 *
17 nmol/l insulin + 30 μmol/l ZnCl20.069 ± 0.0100.056 ± 0.006 *
30 μmol/l ZnCl20.097 ± 0.0120.060 ± 0.010 *
  • Data are the means ± SE for seven separate experiments. The effects of insulin, wortmannin, or ZnCl2 were tested on glucagon secretion at either 0.5 or 10 mmol/l glucose in mouse islets.

  • *

    * P ≤ 0.05 vs. 0.5 mmol/l glucose.