TABLE 1

Effects of pancreatic-specific IGF-I gene deficiency on body weight and blood biochemistry in PID mice

ControlPIDP
Body weight (g)
    Female19.9 ± 0.4 (21)19.7 ± 0.5 (14)NS
    Male25.1 ± 0.8 (10)25.6 ± 0.8 (10)NS
Serum IGF-I level (ng/ml)
    Female370 ± 13 (13)348 ± 10 (18)0.18
    Male364 ± 13 (14)343 ± 9 (14)0.19
Serum insulin level (ng/ml)
    Female0.79 ± 0.25 (11)0.39 ± 0.05 (18)0.062
    Male0.92 ± 0.25 (14)0.59 ± 0.16 (14)0.25
Serum glucagon level (ng/ml)
    Female148 ± 30 (7)75 ± 20 (10)0.054
    Male87 ± 23 (10)36 ± 5 (8)0.058
Blood glucose level (mg/dl)
    Female151 ± 4 (21)127 ± 5 (14)0.0003
    Male158 ± 7 (10)128 ± 5 (10)0.002
  • Data are means ± SE (n). Mice were 3 months old and under random-fed status. P values are derived from unpaired Student’s t test vs. same-sex control littermates.