TABLE 2

Hepatic lipid content in ob/ob, ob/+, STZ-treated, and vehicle-treated control mice

ob/obob/+§STZ-treated (blood glucose ≥13.1 mmol/l)STZ-treated (blood glucose <13.1 mmol/l)Controls
Number of mice1010121224
Triglycerides (nmol/mg wet wt)136.37 ± 1.1610.61 ± 1.087.21 ± 0.498.73 ± 0.6116.01 ± 1.00
Free cholesterol (nmol/mg wet wt)2.81 ± 0.184.49 ± 0.243.36 ± 0.11*3.40 ± 0.17*3.82 ± 0.11
Cholesterol esters (nmol/mg wet wt)3.06 ± 0.281.42 ± 0.300.99 ± 0.121.55 ± 0.221.72 ± 16
Sphingomyelin (μg/mg wet wt)0.32 ± 0.01*0.57 ± 0.070.55 ± 0.020.53 ± 0.050.55 ± 0.03
Phosphatidylcholine (μg/mg wet wt)15.68 ± 0.41*17.93 ± 0.5219.17 ± 0.7618.72 ± 0.9419.69 ± 0.70
Phosphatidylserine (μg/mg wet wt)0.99 ± 0.05*1.53 ± 0.221.59 ± 0.061.62 ± 0.081.77 ± 0.06
Phosphatidylinositol (μg/mg wet wt)2.82 ± 0.083.39 ± 0.293.42 ± 0.123.41 ± 0.203.71 ± 0.13
Phosphatidylethanolamine (μg/mg wet wt)5.64 ± 0.247.87 ± 0.3311.15 ± 0.6010.68 ± 0.66*12.56 ± 0.53
Cardiolipin (μg/mg wet wt)1.62 ± 0.122.27 ± 0.091.98 ± 0.081.97 ± 0.101.98 ± 0.07
  • Data are means ± SE.

  • *

    * P < 0.05,

  • P < 0.005,

  • P < 0.0005 compared with controls.

  • §

    § Controls for ob/ob mice; vehicle-treated controls for STZ-treated mice.