TABLE 1

Basic metabolic variables in ob/ob, STZ-treated, and control mice

ob/obob/+ controlsSTZ-treated (blood glucose ≥13.1 mmol/l)STZ-treated (blood glucose <13.1 mmol/l)Vehicle-treated controls
Number of mice1010171734
Body weight (g)43.3 ± 1.421.0 ± 0.424.4 ± 1.022.8 ± 0.926.7 ± 0.8
Fasting blood glucose (mmol/l)15.1 ± 0.98.1 ± 0.317.2 ± 0.78.5 ± 0.46.6 ± 0.1
Plasma insulin (pmol/l)§2400 ± 208121 ± 1569 ± 5.5106 ± 10.6
Plasma total cholesterol (mmol/l)3.83 ± 0.191.66 ± 0.092.46 ± 0.102.17 ± 0.062.11 ± 0.08
Plasma HDL cholesterol (mmol/l)1.61 ± 0.08*1.39 ± 0.061.88 ± 0.111.82 ± 0.071.66 ± 0.06
Plasma VLDL+LDL cholesterol (mmol/l)2.23 ± 0.160.28 ± 0.130.59 ± 0.090.35 ± 0.060.48 ± 0.07
Plasma triglycerides (mmol/l)1.05 ± 0.190.94 ± 0.051.42 ± 0.110.82 ± 0.070.81 ± 0.04
Plasma free fatty acids (mmol/l)0.27 ± 0.020.23 ± 0.020.30 ± 0.020.29 ± 0.020.30 ± 0.01
  • Data are means ± SD. Blood samples for glucose and plasma lipid analysis were taken at the end of the experiment after fasting the mice for 4 h. Values are mean ± SE.

  • *

    * P < 0.05;

  • P < 0.01;

  • P < 0.0005 compared with controls.

  • §

    § Determined on pooled plasma aliquots from two to four mice.