TABLE 6

Cardiovascular disease status of the study patients

Creatinine clearance (ml · min−1 · 1.73 m−2)
≥9070–8950–6930–49
n205692918
Coronary artery disease*14 (6.8)5 (7.3)5 (17.2)4 (22.2)
 Angina pectoris10442
 Myocardial infarction4112
Cerebrovascular disease*6 (2.9)3 (4.3)4 (5.8)2 (11.1)
 Atherosclerotic plaques42
 TIA or PRIND111
 Atherothrombotic stroke1131
Peripheral vascular disease*8 (3.9)3 (4.3)3 (10.3)4 (22.2)
 Atherosclerotic plaques5211
 Symptomatic arterial occlusive disease3122
 Aortic aneurysm1
Total number of events28111210
Number of subjects with events22 (10.7)10 (14.5)9 (31.0)7 (38.9)
  • *

    * P < 0.05 by Pearson χ2 test;

  • P < 0.001 by Perason χ2 test. Carotid arteries, abdominal aorta, and iliac and femoral arteries were evaluated with a B-mode ultrasound system equipped with a 7.5-MHz transducer. Examination was performed in the supine position, and multiple projections were used. Atherosclerotic lesions were defined by the presence of plaques at least 50% greater than the surrounding wall. PRIND, prolonged reversible ischemic neurologic deficit; TIA, transitory ischemic attack.