TABLE 5

Clinical and glucose metabolism parameters in patients with and without microalbuminuria

Microalbuminuria ≤30 mg/dayMicroalbuminuria >30 mg/day
n208113
Age (years)53 ± 1154 ± 12
Systolic blood pressure (mmHg)164 ± 23171 ± 22*
Diastolic blood pressure (mmHg)101 ± 13102 ± 10
Duration of hypertension (months)50 ± 6189 ± 94*
BMI (kg/m2)26.8 ± 3.227.1 ± 3.6
Serum creatinine (μmol/l)89.4 ± 17.796.5 ± 36.3
Creatinine clearance (ml · min−1 · 1.73 m−2)100.9 ± 28.792.9 ± 31.8
Microalbuminuria (mg/day)8.1 ± 4.991.7 ± 191.0*
Fasting glucose (mmol/l)4.94 ± 0.894.99 ± 1.44
Fasting insulin (pmol/l)78.2 ± 35.975.3 ± 40.2
Fasting C-peptide (nmol/l)0.71 ± 0.310.81 ± 0.49
Fasting glucose-to-insulin ratio × 1006.32 ± 3.866.63 ± 3.49
AUC blood glucose (mmol · l−1 · min)24.1 ± 7.123.8 ± 7.7
AUC plasma insulin (pmol · l−1 · min)1,134 ± 667971 ± 610
Glucose MCR (ml · kg−1 · min)15.2 ± 2.615.0 ± 2.9
  • Data are means ± SD. Comparisons are by Student t test.

  • *

    * P < 0.001 vs. patients without microalbuminuria;

  • P < 0.05 vs. patients without microalbuminuria. AUC for blood glucose and serum insulin concentration 180 min after oral glucose load. MCR was assessed during the hyperinsulinemic-euglycemic clamp. Glucose MCR was assessed by a hyperinsulinemic-euglycemic clamp in a subgroup of 104 patients (56 without microalbuminuria and 48 with microalbuminuria). To convert to conventional units, multiply creatinine by 0.0113 (mg/dl), glucose by 0.05551 (mg/dl), insulin by 7.175 (μU/ml), and C-peptide by 3.021 (ng/ml).