TABLE 3

Glucose metabolism parameters of the study patients

Creatinine clearance (ml · min−1 · 1.73 m−2)
≥9070–8950–6930–49
n205692918
Fasting glucose (mmol/l)5.05 ± 0.945.10 ± 1.444.77 ± 1.174.76 ± 1.33
Fasting insulin (pmol/l)73.2 ± 19.578.2 ± 20.973.9 ± 27.390.3 ± 28.0*
Fasting C-peptide (nmol/l)0.73 ± 0.290.72 ± 0.390.73 ± 0.361.47 ± 1.04
Fasting glucose-to-insulin ratio × 1006.90 ± 2.756.52 ± 2.907.46 ± 4.355.25 ± 2.07*
AUC blood glucose (mmol · l−1 · min)23.8 ± 6.724.1 ± 8.625.1 ± 10.633.1 ± 5.3
AUC plasma insulin (pmol · l−1 · min)1,054 ± 6031,033 ± 581954 ± 6741,722 ± 1,011
Glucose MCR (ml · kg−1 · min)15.6 ± 2.214.8 ± 3.415.1 ± 3.111.2 ± 2.9*
  • Data are means ± SD. Comparisons are by one-way ANOVA.

  • *

    * P < 0.05 vs. patients with creatinine clearance ≥90 ml · min−1 · 1.73 m−2;

  • P < 0.001 vs. patients with creatinine clearance ≥90 ml · min−1 · 1.73 m−2. AUC for blood glucose and serum insulin concentration 180 min after oral glucose load. Glucose MCR was assessed by a hyperinsulinemic-euglycemic clamp in a subgroup of 104 patients (creatinine clearance ≥90 ml · min−1 · 1.73 m−2, n = 42; 70–89 ml · min−1 · 1.73 m−2, n = 32; 50–69 ml · min−1 · 1.73 m−2, n = 19; 30–49 ml · min−1 · 1.73 m−2, n = 11). To convert to conventional units, multiply glucose by 0.05551 (mg/dl), insulin by 7.175 (μU/ml), and C-peptide by 3.021 (ng/ml).