TABLE 2

Clinical, lipid, and renal parameters of the hypertensive patients according to creatinine clearance values

Creatinine clearance (ml · min−1 · 1.73 m−2)
≥9070–8950–6930–49
n205692918
Age (years)52 ± 1154 ± 1256 ± 1460 ± 14*
Sex (M/F)120/8538/3116/1310/8
Systolic blood pressure (mmHg)164 ± 25172 ± 22178 ± 22*179 ± 24*
Diastolic blood pressure (mmHg)101 ± 13102 ± 12101 ± 12102 ± 10
Duration of hypertension (months)52 ± 6966 ± 5289 ± 73105 ± 71
BMI (kg/m2)26.8 ± 3.326.7 ± 4.126.4 ± 2.826.6 ± 3.9
Waist-to-hip ratio0.92 ± 0.080.91 ± 0.090.92 ± 0.070.91 ± 1.10
Current smokers (%)36413839
Total cholesterol (mmol/l)5.44 ± 1.145.48 ± 0.995.47 ± 1.045.50 ± 1.13
LDL cholesterol (mmol/l)3.47 ± 1.043.52 ± 0.883.48 ± 0.913.52 ± 1.09
HDL cholesterol (mmol/l)1.32 ± 0.391.32 ± 0.391.33 ± 0.281.31 ± 0.43
Triglycerides (mmol/l)1.31 ± 0.761.43 ± 0.791.51 ± 0.821.79 ± 0.81*
Free fatty acids (mg/l)176 ± 23174 ± 21180 ± 27181 ± 26
Serum creatinine (μmol/l)86.7 ± 12.4102.7 ± 17.7114.2 ± 29.2198.2 ± 79.6
Creatinine clearance (ml · min−1 · 1.73 m−2)117.2 ± 23.179.3 ± 5.661.2 ± 4.234.6 ± 4.3
Urinary protein excretion (mg/day)220 ± 172219 ± 203329 ± 332538 ± 529
Microalbuminuria (mg/day)22 ± 2734 ± 92118 ± 314187 ± 302
  • Data are means ± SD. Comparisons are by two-way ANOVA or Pearson χ2 test.

  • *

    * P < 0.05 vs. patients with creatinine clearance ≥90 ml · min−1 · 1.73 m−2;

  • P < 0.01 vs. patients with creatinine clearance ≥90 ml · min−1 · 1.73 m−2;

  • P < 0.001 vs. patients with creatinine clearance ≥90 ml · min−1 · 1.73 m−2. To convert to conventional units, multiply creatinine by 0.0113 (mg/dl), cholesterol by 38.6 (mg/dl), and triglycerides by 88.5 (mg/dl).