TABLE 1

Clinical, lipid, and glucose metabolism parameters of the hypertensive patients and control subjects

Control subjectsHypertensive patientsP
n92321
Age (years)52 ± 1853 ± 120.532
Sex (M/F)48/44184/1370.448
Systolic blood pressure (mmHg)125 ± 13168 ± 24<0.001
Diastolic blood pressure (mmHg)78 ± 12101 ± 13<0.001
BMI (kg/m2)26.2 ± 3.326.8 ± 3.60.152
Waist-to-hip ratio0.91 ± 0.090.91 ± 0.101.000
Serum creatinine (μmol/l)90 ± 3198 ± 280.019
Total cholesterol (mmol/l)5.30 ± 1.035.45 ± 1.840.455
LDL cholesterol (mmol/l)3.34 ± 0.963.48 ± 1.020.240
HDL cholesterol (mmol/l)1.42 ± 0.411.2 ± 0.380.029
Triglycerides (mmol/l)1.26 ± 0.551.43 ± 0.770.049
Fasting glucose (mmol/l)4.8 ± 0.85.0 ± 1.20.133
Fasting insulin (pmol/l)60.2 ± 17.477.3 ± 38.7<0.001
Fasting C-peptide (nmol/l)0.55 ± 0.210.76 ± 0.39<0.001
Fasting glucose-to-insulin ratio × 1008.00 ± 2.156.46 ± 2.71<0.001
AUC blood glucose (mmol · 1−1 · min)22.0 ± 6.124.3 ± 7.70.009
AUC plasma insulin (pmol · 1−1 · min)864 ± 4461,062 ± 6320.005
  • Data are means ± SD. Comparisons are by Student’s t test or Pearson χ2 test. To convert to conventional units, multiply creatinine by 0.0113 (mg/dl), cholesterol by 38.6 (mg/dl), and triglycerides by 88.5 (mg/dl); glucose by 0.05551 (mg/dl), insulin by 7.175 (μU/ml), and C-peptide by 3.021 (ng/ml). AUC for blood glucose and serum insulin concentration 180 min after oral glucose load.