Table 1

Replicated SNP associations with UACR in individuals with diabetes

Sample size (n)Effect on log(UACR) mg/gSEP valueI2 %
rs649529, RAB38
 Discovery5,825−0.150.039.3 × 10−60
 Replication1,962−0.120.050.020
 Combined7,787−0.140.035.8 × 10−70
rs13427836, HS6ST1
 Discovery5,5090.200.046.1 × 10−610
 Replication1,8900.160.070.0358
 Combined7,3990.190.046.3 × 10−730
  • For both variants, the effect of each additional copy of the minor allele (T) on UACR was modeled in an additive fashion. I2 is provided as a measure of heterogeneity across studies. Imputation quality ranged from 0.41 to 1.0 for rs649529 and from 0.44 to 1.0 for rs13427836. The variants were directly genotyped in four of the replication studies, with a call rate ranging from 0.98 to 1.0 for rs649529 and from 0.99 to 1.0 for rs13427836. The estimated proportion of explained variance in UACR among those with diabetes is 0.6% for rs649529 and 0.5% for rs13427836, using the formula 2 × MAF × (1-MAF) × effect2/var(log[UACR]), based on the combined effect estimates from Table 1 and the phenotypic variance in the large population-based ARIC Study.