Table 2

Day 2 cardiovascular parameters in overnight-fasted healthy individuals following each day 1 experimental condition

Prior eugly control (no alprazolam)Prior eugly alprazolamPrior hypo control (no alprazolam)Prior hypo alprazolam
ParameterBaselineFinalBaselineFinalBaselineFinalBaselineFinal
Systolic blood pressure (mmHg)111 ± 7145 ± 15*107 ± 5137 ± 7*110 ± 6148 ± 10*111 ± 3140 ± 3*
Diastolic blood pressure (mmHg)65 ± 773 ± 3*66 ± 475 ± 9*65 ± 573 ± 3*68 ± 172 ± 3*
Mean arterial pressure (mmHg)80 ± 396 ± 10*79 ± 396 ± 7*81 ± 592 ± 9*82 ± 494 ± 7*
Heart rate (beats/min)63 ± 5139 ± 7*64 ± 3132 ± 2*60 ± 4147 ± 8*67 ± 3135 ± 5*
  • Data are mean ± SE. eugly, euglycemia; hypo, hypoglycemia.

  • *P < 0.006–0.0001, significantly increased compared with baseline value.