Table 1

Day 2 baseline neuroendocrine, EGP, and intermediary metabolite values in overnight-fasted healthy individuals following each day 1 experimental condition

Baseline valuesPrior eugly control 
(no alprazolam)Prior eugly alprazolamPrior hypo control 
(no alprazolam)Prior hypo alprazolam
Epinephrine (pmol/L)191 ± 39196 ± 38139 ± 43158 ± 54
Norepinephrine (nmol/L)1.4 ± 0.21.6 ± 0.11.4 ± 0.21.5 ± 0.2
Glucagon (ng/L)42 ± 346 ± 944 ± 346 ± 4
Growth hormone (µg/L)2.7 ± 22.9 ± 12.4 ± 0.62.2 ± 0.1
Cortisol (nmol/L)306 ± 55419 ± 82286 ± 83333 ± 55
Pancreatic polypeptide (pmol/L)18 ± 321 ± 119 ± 221 ± 6
EGP (μmol/kg/min)10.4 ± 0.59.3 ± 1.611 ± 0.58.8 ± 0.5
NEFA (μmol/L)332 ± 50325 ± 62337 ± 57273 ± 52
Lactate (mmol/L)1.07 ± 0.11.01 ± 0.11.0 ± 0.20.7 ± 0.1
Glycerol (μmol/L)66 ± 1076 ± 1351 ± 1254 ± 7
  • Data are mean ± SE. eugly, euglycemia; hypo, hypoglycemia.