Table 1

Characteristics of FDRs participating in the BOX family study whose samples were originally screened for GADAs using a local assay and were reassayed using the standard method with 35S-labeled GAD65(1–585) and GAD65(96–585)

GADA positiveGADA negative
Nonprogressors
(n = 213)Progressors
(n = 70)Nonprogressors
(n = 428)Progressors
(n = 31)
Male1023720423
Median age, years (range)31.5 (1.3–57.4)30.9 (1.6–52.9)32.7 (1.7–57.3)39 (1.4–56)
Median age at diagnosis, years (range)38 (3.2–69.8)52 (3.3–68.5)
Median follow-up, years (range)14.9 (0.6–27.7)7.2 (0.2–24.2)15.2 (0–27.6)12.3 (1.2–23.8)
Additional autoantibodies*3739114
IA-2A132202
IAA2323113
ZnT8A19271
  • Data are number of FDRs or median (range).

  • *Additional autoantibodies are from IA-2A, IAA, and ZnT8A.

  • †Not assayed for ZnT8A.