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Table of Contents

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June 01 2017; volume 66 issue 6

In This Issue

  • Open Access
    In This Issue of Diabetes
    Diabetes 2017 Jun; 66 (6): 1429-1430. https://doi.org/10.2337/db17-ti06
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Editor's Note

  • Open Access
    A Special Thanks to the Reviewers of Diabetes
    Diabetes 2017 Jun; 66 (6): 1431. https://doi.org/10.2337/db17-en06
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Perspectives in Diabetes

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    Type 2 Diabetes: Demystifying the Global Epidemic
    Ranjit Unnikrishnan, Rajendra Pradeepa, Shashank R. Joshi and Viswanathan Mohan
    Diabetes 2017 Jun; 66 (6): 1432-1442. https://doi.org/10.2337/db16-0766
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    Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?
    Allison L. O’Kell, Clive Wasserfall, Brian Catchpole, Lucy J. Davison, Rebecka S. Hess, Jake A. Kushner and Mark A. Atkinson
    Diabetes 2017 Jun; 66 (6): 1443-1452. https://doi.org/10.2337/db16-1551
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    GLP-1R as a Target for the Treatment of Diabetic Retinopathy: Friend or Foe?
    Rafael Simó and Cristina Hernández
    Diabetes 2017 Jun; 66 (6): 1453-1460. https://doi.org/10.2337/db16-1364
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Commentaries

  • Open Access
    Diabetes: Leveraging the Tipping Point of the Diabetes Pandemic
    Jian-Ping Weng and Gang Hu
    Diabetes 2017 Jun; 66 (6): 1461-1463. https://doi.org/10.2337/dbi16-0076
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  • Open Access
    The COX-2/PGE2/EP3/Gi/o/cAMP/GSIS Pathway in the Islet: The Beat Goes On
    R. Paul Robertson
    Diabetes 2017 Jun; 66 (6): 1464-1466. https://doi.org/10.2337/dbi17-0017
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  • Open Access
    Checks and Balances—The Limits of β-Cell Endurance to ER Stress
    Decio L. Eizirik and Alexandra Coomans de Brachène
    Diabetes 2017 Jun; 66 (6): 1467-1469. https://doi.org/10.2337/dbi17-0018
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Technological Advances

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    Functional Human Beige Adipocytes From Induced Pluripotent Stem Cells
    Anne-Claire Guénantin, Nolwenn Briand, Emilie Capel, Florent Dumont, Romain Morichon, Claire Provost, Francesca Stillitano, Dorota Jeziorowska, Jean-Pierre Siffroi, Roger J. Hajjar, Bruno Fève, Jean-Sébastien Hulot, Philippe Collas, Jacqueline Capeau and Corinne Vigouroux
    Diabetes 2017 Jun; 66 (6): 1470-1478. https://doi.org/10.2337/db16-1107
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Metabolism

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    VEGF-A–Expressing Adipose Tissue Shows Rapid Beiging and Enhanced Survival After Transplantation and Confers IL-4–Independent Metabolic Improvements
    Jiyoung Park, Min Kim, Kai Sun, Yu Aaron An, Xue Gu and Philipp E. Scherer
    Diabetes 2017 Jun; 66 (6): 1479-1490. https://doi.org/10.2337/db16-1081
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    GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle
    Shawna L. McMillin, Denise L. Schmidt, Barbara B. Kahn and Carol A. Witczak
    Diabetes 2017 Jun; 66 (6): 1491-1500. https://doi.org/10.2337/db16-1075
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    Exercise Increases Human Skeletal Muscle Insulin Sensitivity via Coordinated Increases in Microvascular Perfusion and Molecular Signaling
    Kim A. Sjøberg, Christian Frøsig, Rasmus Kjøbsted, Lykke Sylow, Maximilian Kleinert, Andrew C. Betik, Christopher S. Shaw, Bente Kiens, Jørgen F.P. Wojtaszewski, Stephen Rattigan, Erik A. Richter and Glenn K. McConell
    Diabetes 2017 Jun; 66 (6): 1501-1510. https://doi.org/10.2337/db16-1327
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    Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons
    Luis Varela, Shigetomo Suyama, Yan Huang, Marya Shanabrough, Matthias H. Tschöp, Xiao-Bing Gao, Frank J. Giordano and Tamas L. Horvath
    Diabetes 2017 Jun; 66 (6): 1511-1520. https://doi.org/10.2337/db16-1106
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    Palmitate-Induced Vacuolar-Type H+-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction
    Yilin Liu, Laura K.M. Steinbusch, Miranda Nabben, Dimitris Kapsokalyvas, Marc van Zandvoort, Patrick Schönleitner, Gudrun Antoons, Peter J. Simons, Will A. Coumans, Amber Geomini, Dipanjan Chanda, Jan F.C. Glatz, Dietbert Neumann and Joost J.F.P. Luiken
    Diabetes 2017 Jun; 66 (6): 1521-1534. https://doi.org/10.2337/db16-0727
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    Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance Through ERα/HGF/Met Pathway
    Yu-Yao Zhang, Chao Li, Gao-Feng Yao, Lin-Juan Du, Yuan Liu, Xiao-Jun Zheng, Shuai Yan, Jian-Yong Sun, Yan Liu, Ming-Zhu Liu, Xiaoran Zhang, Gang Wei, Wenxin Tong, Xiaobei Chen, Yong Wu, Shuyang Sun, Suling Liu, Qiurong Ding, Ying Yu, Huiyong Yin and Sheng-Zhong Duan
    Diabetes 2017 Jun; 66 (6): 1535-1547. https://doi.org/10.2337/db16-1354
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    Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise
    Lykke Sylow, Lisbeth L.V. Møller, Maximilian Kleinert, Gommaar D’Hulst, Estelle De Groote, Peter Schjerling, Gregory R. Steinberg, Thomas E. Jensen and Erik A. Richter
    Diabetes 2017 Jun; 66 (6): 1548-1559. https://doi.org/10.2337/db16-1138
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    Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action
    Andrew C. Shin, Nika Filatova, Claudia Lindtner, Tiffany Chi, Seta Degann, Douglas Oberlin and Christoph Buettner
    Diabetes 2017 Jun; 66 (6): 1560-1571. https://doi.org/10.2337/db16-1238
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Signal Transduction

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    Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E2 Signaling and Enhances Diabetic β-Cell Function
    Joshua C. Neuman, Michael D. Schaid, Allison L. Brill, Rachel J. Fenske, Carly R. Kibbe, Danielle A. Fontaine, Sophia M. Sdao, Harpreet K. Brar, Kelsey M. Connors, Haley N. Wienkes, Kevin W. Eliceiri, Matthew J. Merrins, Dawn B. Davis and Michelle E. Kimple
    Diabetes 2017 Jun; 66 (6): 1572-1585. https://doi.org/10.2337/db16-1362
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    MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca2+–Dependent Antioxidant Response
    Lele Ji, Fengzhou Liu, Zhe Jing, Qichao Huang, Ya Zhao, Haiyan Cao, Jun Li, Chun Yin, Jinliang Xing and Fei Li
    Diabetes 2017 Jun; 66 (6): 1586-1600. https://doi.org/10.2337/db16-1237
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    Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis
    Taiyi Kuo, Tzu-Chieh Chen, Rebecca A. Lee, Nguyen Huynh Thao Nguyen, Augusta E. Broughton, Danyun Zhang and Jen-Chywan Wang
    Diabetes 2017 Jun; 66 (6): 1601-1610. https://doi.org/10.2337/db16-0831
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Obesity Studies

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    Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning
    Mallikarjun Patil, Bal Krishan Sharma, Sawsan Elattar, Judith Chang, Shweta Kapil, Jinling Yuan and Ande Satyanarayana
    Diabetes 2017 Jun; 66 (6): 1611-1625. https://doi.org/10.2337/db16-1079
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Islet Studies

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    β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation
    Brandon L. Panaro, Grace B. Flock, Jonathan E. Campbell, Jacqueline L. Beaudry, Xiemin Cao and Daniel J. Drucker
    Diabetes 2017 Jun; 66 (6): 1626-1635. https://doi.org/10.2337/db17-0017
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    Arginase-II Promotes Tumor Necrosis Factor-α Release From Pancreatic Acinar Cells Causing β-Cell Apoptosis in Aging
    Yuyan Xiong, Gautham Yepuri, Sevil Necetin, Jean-Pierre Montani, Xiu-Fen Ming and Zhihong Yang
    Diabetes 2017 Jun; 66 (6): 1636-1649. https://doi.org/10.2337/db16-1190
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Immunology and Transplantation

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    Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice
    Prerak M. Trivedi, Kate L. Graham, Nicholas A. Scott, Misty R. Jenkins, Suktilang Majaw, Robyn M. Sutherland, Stacey Fynch, Andrew M. Lew, Christopher J. Burns, Balasubramanian Krishnamurthy, Thomas C. Brodnicki, Stuart I. Mannering, Thomas W. Kay and Helen E. Thomas
    Diabetes 2017 Jun; 66 (6): 1650-1660. https://doi.org/10.2337/db16-1250
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Pathophysiology

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    The Effect of Diabetes on Cortical Function in Stroke: Implications for Poststroke Plasticity
    William Huynh, Natalie Kwai, Ria Arnold, Arun V. Krishnan, Cindy S.-Y. Lin, Steve Vucic and Matthew C. Kiernan
    Diabetes 2017 Jun; 66 (6): 1661-1670. https://doi.org/10.2337/db16-0961
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Complications

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    Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARα
    Qian Chen, Fangfang Qiu, Kelu Zhou, H. Greg Matlock, Yusuke Takahashi, Raju V.S. Rajala, Yanhui Yang, Elizabeth Moran and Jian-xing Ma
    Diabetes 2017 Jun; 66 (6): 1671-1682. https://doi.org/10.2337/db16-1246
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    RAGE-Aptamer Blocks the Development and Progression of Experimental Diabetic Nephropathy
    Takanori Matsui, Yuichiro Higashimoto, Yuri Nishino, Nobutaka Nakamura, Kei Fukami and Sho-ichi Yamagishi
    Diabetes 2017 Jun; 66 (6): 1683-1695. https://doi.org/10.2337/db16-1281
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    High-Intensity Exercise as a Dishabituating Stimulus Restores Counterregulatory Responses in Recurrently Hypoglycemic Rodents
    Alison D. McNeilly, Jennifer R. Gallagher, Jeffrey T.-J. Huang, Michael L.J. Ashford and Rory J. McCrimmon
    Diabetes 2017 Jun; 66 (6): 1696-1702. https://doi.org/10.2337/db16-1533
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Genetics/Genomes/Proteomics/Metabolomics

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    A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response
    Zachary Pappalardo, Deeksha Gambhir Chopra, Thomas G. Hennings, Hunter Richards, Justin Choe, Katherine Yang, Luc Baeyens, Kenny Ang, Steven Chen, Michelle Arkin, Michael S. German, Michael T. McManus and Gregory M. Ku
    Diabetes 2017 Jun; 66 (6): 1703-1712. https://doi.org/10.2337/db16-0962
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    Role of DNA Methylation in Type 2 Diabetes Etiology: Using Genotype as a Causal Anchor
    Hannah R. Elliott, Hashem A. Shihab, Gabrielle A. Lockett, John W. Holloway, Allan F. McRae, George Davey Smith, Susan M. Ring, Tom R. Gaunt and Caroline L. Relton
    Diabetes 2017 Jun; 66 (6): 1713-1722. https://doi.org/10.2337/db16-0874
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    An Exome-Chip Association Analysis in Chinese Subjects Reveals a Functional Missense Variant of GCKR That Regulates FGF21 Levels
    Chloe Y.Y. Cheung, Clara S. Tang, Aimin Xu, Chi-Ho Lee, Ka-Wing Au, Lin Xu, Carol H.Y. Fong, Kelvin H.M. Kwok, Wing-Sun Chow, Yu-Cho Woo, Michele M.A. Yuen, Stacey S. Cherny, JoJo Hai, Bernard M.Y. Cheung, Kathryn C.B. Tan, Tai-Hing Lam, Hung-Fat Tse, Pak-Chung Sham and Karen S.L. Lam
    Diabetes 2017 Jun; 66 (6): 1723-1728. https://doi.org/10.2337/db16-1384
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Statement of Retraction

  • Open Access
    Statement of Retraction. Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets. Diabetes 2008;57:645–653. DOI: 10.2337/db07-0847; and erratum. Diabetes 2014:63:3974. DOI: 10.2337/db14-er11
    Luan Shu, Nadine S. Sauter, Fabienne T. Schulthess, Aleksey V. Matveyenko, José Oberholzer and Kathrin Maedler
    Diabetes 2017 Jun; 66 (6): 1729-1730. https://doi.org/10.2337/db17-rt06a
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Issues and Events

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    Issues and Events
    Diabetes 2017 Jun; 66 (6): 1731. https://doi.org/10.2337/db17-ie06
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Diabetes: 66 (6)

In this Issue

June 2017, 66(6)
  • Table of Contents
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  • Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
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