Diabetes: 66 (6)

June 01 2017; volume 66 issue 6

In This Issue

Open Access
In This Issue of Diabetes
Diabetes 2017 Jun; 66 (6): 1429-1430. https://doi.org/10.2337/db17-ti06

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Editor's Note

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A Special Thanks to the Reviewers of Diabetes
Diabetes 2017 Jun; 66 (6): 1431. https://doi.org/10.2337/db17-en06

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Perspectives in Diabetes

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Type 2 Diabetes: Demystifying the Global Epidemic
Ranjit Unnikrishnan, Rajendra Pradeepa, Shashank R. Joshi and Viswanathan Mohan

Diabetes 2017 Jun; 66 (6): 1432-1442. https://doi.org/10.2337/db16-0766

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Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?
Allison L. O’Kell, Clive Wasserfall, Brian Catchpole, Lucy J. Davison, Rebecka S. Hess, Jake A. Kushner and Mark A. Atkinson

Diabetes 2017 Jun; 66 (6): 1443-1452. https://doi.org/10.2337/db16-1551

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GLP-1R as a Target for the Treatment of Diabetic Retinopathy: Friend or Foe?
Rafael Simó and Cristina Hernández

Diabetes 2017 Jun; 66 (6): 1453-1460. https://doi.org/10.2337/db16-1364

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Commentaries

Open Access
Diabetes: Leveraging the Tipping Point of the Diabetes Pandemic
Jian-Ping Weng and Gang Hu

Diabetes 2017 Jun; 66 (6): 1461-1463. https://doi.org/10.2337/dbi16-0076

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The COX-2/PGE₂/EP3/G_i/o/cAMP/GSIS Pathway in the Islet: The Beat Goes On
R. Paul Robertson

Diabetes 2017 Jun; 66 (6): 1464-1466. https://doi.org/10.2337/dbi17-0017

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Checks and Balances—The Limits of β-Cell Endurance to ER Stress
Decio L. Eizirik and Alexandra Coomans de Brachène

Diabetes 2017 Jun; 66 (6): 1467-1469. https://doi.org/10.2337/dbi17-0018

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Technological Advances

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Functional Human Beige Adipocytes From Induced Pluripotent Stem Cells
Anne-Claire Guénantin, Nolwenn Briand, Emilie Capel, Florent Dumont, Romain Morichon, Claire Provost, Francesca Stillitano, Dorota Jeziorowska, Jean-Pierre Siffroi, Roger J. Hajjar, Bruno Fève, Jean-Sébastien Hulot, Philippe Collas, Jacqueline Capeau and Corinne Vigouroux

Diabetes 2017 Jun; 66 (6): 1470-1478. https://doi.org/10.2337/db16-1107

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Metabolism

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VEGF-A–Expressing Adipose Tissue Shows Rapid Beiging and Enhanced Survival After Transplantation and Confers IL-4–Independent Metabolic Improvements
Jiyoung Park, Min Kim, Kai Sun, Yu Aaron An, Xue Gu and Philipp E. Scherer

Diabetes 2017 Jun; 66 (6): 1479-1490. https://doi.org/10.2337/db16-1081

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GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle
Shawna L. McMillin, Denise L. Schmidt, Barbara B. Kahn and Carol A. Witczak

Diabetes 2017 Jun; 66 (6): 1491-1500. https://doi.org/10.2337/db16-1075

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Exercise Increases Human Skeletal Muscle Insulin Sensitivity via Coordinated Increases in Microvascular Perfusion and Molecular Signaling
Kim A. Sjøberg, Christian Frøsig, Rasmus Kjøbsted, Lykke Sylow, Maximilian Kleinert, Andrew C. Betik, Christopher S. Shaw, Bente Kiens, Jørgen F.P. Wojtaszewski, Stephen Rattigan, Erik A. Richter and Glenn K. McConell

Diabetes 2017 Jun; 66 (6): 1501-1510. https://doi.org/10.2337/db16-1327

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Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons
Luis Varela, Shigetomo Suyama, Yan Huang, Marya Shanabrough, Matthias H. Tschöp, Xiao-Bing Gao, Frank J. Giordano and Tamas L. Horvath

Diabetes 2017 Jun; 66 (6): 1511-1520. https://doi.org/10.2337/db16-1106

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Palmitate-Induced Vacuolar-Type H⁺-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction
Yilin Liu, Laura K.M. Steinbusch, Miranda Nabben, Dimitris Kapsokalyvas, Marc van Zandvoort, Patrick Schönleitner, Gudrun Antoons, Peter J. Simons, Will A. Coumans, Amber Geomini, Dipanjan Chanda, Jan F.C. Glatz, Dietbert Neumann and Joost J.F.P. Luiken

Diabetes 2017 Jun; 66 (6): 1521-1534. https://doi.org/10.2337/db16-0727

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Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance Through ERα/HGF/Met Pathway
Yu-Yao Zhang, Chao Li, Gao-Feng Yao, Lin-Juan Du, Yuan Liu, Xiao-Jun Zheng, Shuai Yan, Jian-Yong Sun, Yan Liu, Ming-Zhu Liu, Xiaoran Zhang, Gang Wei, Wenxin Tong, Xiaobei Chen, Yong Wu, Shuyang Sun, Suling Liu, Qiurong Ding, Ying Yu, Huiyong Yin and Sheng-Zhong Duan

Diabetes 2017 Jun; 66 (6): 1535-1547. https://doi.org/10.2337/db16-1354

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Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise
Lykke Sylow, Lisbeth L.V. Møller, Maximilian Kleinert, Gommaar D’Hulst, Estelle De Groote, Peter Schjerling, Gregory R. Steinberg, Thomas E. Jensen and Erik A. Richter

Diabetes 2017 Jun; 66 (6): 1548-1559. https://doi.org/10.2337/db16-1138

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Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action
Andrew C. Shin, Nika Filatova, Claudia Lindtner, Tiffany Chi, Seta Degann, Douglas Oberlin and Christoph Buettner

Diabetes 2017 Jun; 66 (6): 1560-1571. https://doi.org/10.2337/db16-1238

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Signal Transduction

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Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E₂ Signaling and Enhances Diabetic β-Cell Function
Joshua C. Neuman, Michael D. Schaid, Allison L. Brill, Rachel J. Fenske, Carly R. Kibbe, Danielle A. Fontaine, Sophia M. Sdao, Harpreet K. Brar, Kelsey M. Connors, Haley N. Wienkes, Kevin W. Eliceiri, Matthew J. Merrins, Dawn B. Davis and Michelle E. Kimple

Diabetes 2017 Jun; 66 (6): 1572-1585. https://doi.org/10.2337/db16-1362

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MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca²⁺–Dependent Antioxidant Response
Lele Ji, Fengzhou Liu, Zhe Jing, Qichao Huang, Ya Zhao, Haiyan Cao, Jun Li, Chun Yin, Jinliang Xing and Fei Li

Diabetes 2017 Jun; 66 (6): 1586-1600. https://doi.org/10.2337/db16-1237

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Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis
Taiyi Kuo, Tzu-Chieh Chen, Rebecca A. Lee, Nguyen Huynh Thao Nguyen, Augusta E. Broughton, Danyun Zhang and Jen-Chywan Wang

Diabetes 2017 Jun; 66 (6): 1601-1610. https://doi.org/10.2337/db16-0831

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Obesity Studies

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Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning
Mallikarjun Patil, Bal Krishan Sharma, Sawsan Elattar, Judith Chang, Shweta Kapil, Jinling Yuan and Ande Satyanarayana

Diabetes 2017 Jun; 66 (6): 1611-1625. https://doi.org/10.2337/db16-1079

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Islet Studies

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β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation
Brandon L. Panaro, Grace B. Flock, Jonathan E. Campbell, Jacqueline L. Beaudry, Xiemin Cao and Daniel J. Drucker

Diabetes 2017 Jun; 66 (6): 1626-1635. https://doi.org/10.2337/db17-0017

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Arginase-II Promotes Tumor Necrosis Factor-α Release From Pancreatic Acinar Cells Causing β-Cell Apoptosis in Aging
Yuyan Xiong, Gautham Yepuri, Sevil Necetin, Jean-Pierre Montani, Xiu-Fen Ming and Zhihong Yang

Diabetes 2017 Jun; 66 (6): 1636-1649. https://doi.org/10.2337/db16-1190

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Immunology and Transplantation

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Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice
Prerak M. Trivedi, Kate L. Graham, Nicholas A. Scott, Misty R. Jenkins, Suktilang Majaw, Robyn M. Sutherland, Stacey Fynch, Andrew M. Lew, Christopher J. Burns, Balasubramanian Krishnamurthy, Thomas C. Brodnicki, Stuart I. Mannering, Thomas W. Kay and Helen E. Thomas

Diabetes 2017 Jun; 66 (6): 1650-1660. https://doi.org/10.2337/db16-1250

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Pathophysiology

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The Effect of Diabetes on Cortical Function in Stroke: Implications for Poststroke Plasticity
William Huynh, Natalie Kwai, Ria Arnold, Arun V. Krishnan, Cindy S.-Y. Lin, Steve Vucic and Matthew C. Kiernan

Diabetes 2017 Jun; 66 (6): 1661-1670. https://doi.org/10.2337/db16-0961

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Complications

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Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARα
Qian Chen, Fangfang Qiu, Kelu Zhou, H. Greg Matlock, Yusuke Takahashi, Raju V.S. Rajala, Yanhui Yang, Elizabeth Moran and Jian-xing Ma

Diabetes 2017 Jun; 66 (6): 1671-1682. https://doi.org/10.2337/db16-1246

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RAGE-Aptamer Blocks the Development and Progression of Experimental Diabetic Nephropathy
Takanori Matsui, Yuichiro Higashimoto, Yuri Nishino, Nobutaka Nakamura, Kei Fukami and Sho-ichi Yamagishi

Diabetes 2017 Jun; 66 (6): 1683-1695. https://doi.org/10.2337/db16-1281

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High-Intensity Exercise as a Dishabituating Stimulus Restores Counterregulatory Responses in Recurrently Hypoglycemic Rodents
Alison D. McNeilly, Jennifer R. Gallagher, Jeffrey T.-J. Huang, Michael L.J. Ashford and Rory J. McCrimmon

Diabetes 2017 Jun; 66 (6): 1696-1702. https://doi.org/10.2337/db16-1533

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Genetics/Genomes/Proteomics/Metabolomics

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A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response
Zachary Pappalardo, Deeksha Gambhir Chopra, Thomas G. Hennings, Hunter Richards, Justin Choe, Katherine Yang, Luc Baeyens, Kenny Ang, Steven Chen, Michelle Arkin, Michael S. German, Michael T. McManus and Gregory M. Ku

Diabetes 2017 Jun; 66 (6): 1703-1712. https://doi.org/10.2337/db16-0962

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Role of DNA Methylation in Type 2 Diabetes Etiology: Using Genotype as a Causal Anchor
Hannah R. Elliott, Hashem A. Shihab, Gabrielle A. Lockett, John W. Holloway, Allan F. McRae, George Davey Smith, Susan M. Ring, Tom R. Gaunt and Caroline L. Relton

Diabetes 2017 Jun; 66 (6): 1713-1722. https://doi.org/10.2337/db16-0874

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An Exome-Chip Association Analysis in Chinese Subjects Reveals a Functional Missense Variant of GCKR That Regulates FGF21 Levels
Chloe Y.Y. Cheung, Clara S. Tang, Aimin Xu, Chi-Ho Lee, Ka-Wing Au, Lin Xu, Carol H.Y. Fong, Kelvin H.M. Kwok, Wing-Sun Chow, Yu-Cho Woo, Michele M.A. Yuen, Stacey S. Cherny, JoJo Hai, Bernard M.Y. Cheung, Kathryn C.B. Tan, Tai-Hing Lam, Hung-Fat Tse, Pak-Chung Sham and Karen S.L. Lam

Diabetes 2017 Jun; 66 (6): 1723-1728. https://doi.org/10.2337/db16-1384

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Statement of Retraction

Open Access
Statement of Retraction. Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets. Diabetes 2008;57:645–653. DOI: 10.2337/db07-0847; and erratum. Diabetes 2014:63:3974. DOI: 10.2337/db14-er11
Luan Shu, Nadine S. Sauter, Fabienne T. Schulthess, Aleksey V. Matveyenko, José Oberholzer and Kathrin Maedler

Diabetes 2017 Jun; 66 (6): 1729-1730. https://doi.org/10.2337/db17-rt06a

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Issues and Events

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Issues and Events
Diabetes 2017 Jun; 66 (6): 1731. https://doi.org/10.2337/db17-ie06

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Table of Contents

In This Issue

Editor's Note

Perspectives in Diabetes

Commentaries

Technological Advances

Metabolism

Signal Transduction

Obesity Studies

Islet Studies

Immunology and Transplantation

Pathophysiology

Complications

Genetics/Genomes/Proteomics/Metabolomics

Statement of Retraction

Issues and Events

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